HFE and erythrocyte disorder: Rare mutations in many loci associated with HbA1c (SPTA1ANK1HK1TMPRSS6) are known to cause hereditary red blood cell disorders [7] and common variants at several loci (SPTA1, HFE, ANK1HK1TMPRSS6) are associated with hematological traits like hemoglobin concentration and mean corpuscular volume [32-34].