OGG1 and lung cancer: Mambo et al. [39] analyzed the expression of hOGG1 mRNA in 18 lung cancer and three normal cell lines and found hOGG1 was over expressed in most cell lines, 2/18 (11.1%) showed a lower hOGG1 mRNA and protein expression (∼80% decrease) relative to normal cell lines, indicating 8-Hydroxyguanine repair defects in certain lung cancers.