Disruption of the FXR gene in mice results in a variety of pathophysiological conditions, including a proatherosclerotic lipid profile with increased serum cholesterols and triglycerides [1], cholestasis, non-alcoholic fatty liver diseases, cholesterol gallstone disease, hepatocellular carcinoma, and intestinal inflammation and tumors [5], [6]. The gene discussed is NR1H4; the disease is hepatocellular carcinoma.