On the other hand, SMA is a marker of smooth muscle cells and mature pericytes, which may be derived from hematopoietic stem cells or bone marrow-derived pericyte progenitor cells that are recruited to the brain during glioma angiogenesis, suggesting a ‘long-distance’ effect in recruitment of cells that contribute to tumor angiogenesis [35], [36], [37], [38]. This evidence concerns the gene SMN1 and central nervous system cancer.