Under the aforementioned conditions, OBs derived from the hMSC-TERT cell line underwent a clear dose-dependent increase in mineralization (Figure 3C, left); a slight but reproducible trend towards increased matrix mineralization was also observed in OBs derived from primary MSCs from healthy volunteers and myeloma patients, although it did not reach significance in the latter (Figure 3C, right). This evidence concerns the gene TERT and plasma cell myeloma.