In gut inflammation, such as colitis, an anti-inflammatory role has been attributed to IL-25 in type-1 models of this disease by two separate groups [16, 29], but an exact mechanism of how IL-25 acts to prevent gut inflammation in these models has not been described in full, although IL-25 was associated with the regulation of IL-12 production and induction of alternatively activated macrophages with anti-inflammatory properties [30]. The gene discussed is IL25; the disease is colitis.