TARDBP and proteostasis deficiencies: diTDP-43WT mice showed slowly progressing neurodegeneration, progressive gliosis and punctate cytoplasmic TDP-43 inclusions with ubiquitin immunoreactivity—each of these features closely mimics that observed in human TDP-43 proteinopathies and is not akin to that observed in iTDP-43WT mice (see Supplementary Table 2 for summary).