We examined the brains of iTDP-43WT mice and found that they had striking forebrain atrophy regardless of phenotype (Fig. 2); however, the extent of atrophy and the relative age at which atrophy occurred were dramatically different than observed in human TDP-43 proteinopathies, with almost complete obliteration of neuroanatomical structures, such as the dentate fascia of the hippocampus. The gene discussed is TARDBP; the disease is proteostasis deficiencies.