In this study, we analyzed the expression of RBM5, EGFR, and KRAS genes in NSCLC and adjacent normal tissue specimens and found that RBM5 expression was reduced in NSCLC compared to the normal tissues, whereas expression of both EGFR and KRAS genes was increased in NSCLC compared to the normal tissues. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.