It is further corroborated by other studies, including (1) RBM5 downregulation as a part of a molecular signature of 17 genes for detection of metastasis of multiple solid tumor types [25,26]: solid tumors with these gene signatures had high metastasis rates and poor clinical outcomes, and (2) demonstration that RBM5 may regulate inhibition of metastasis in lung cancer through the upregulation of some metastasis-related genes including Rac1, B-catenin, collagen and laminin [27]. This evidence concerns the gene RAC1 and lung cancer.