ESR1 and neoplasm: Correlation with breast cancer-specific survival was confirmed in a multivariate analysis (including ER, HER2, tumor grade, size, lymph-node status), with RAD21 as a continuous score out of seven (homologous recombination (HR) = 1.66; P = 0.003; 95% CI, 1.19 to 2.32; Table 3).