Similar to our previous findings in sporadic breast cancers [13], high RAD21 expression correlated with poorer relapse-free survival (P = 0.008) and breast cancer-specific survival for grade 3 familial breast cancers (P = 0.009, Figure 2B) [13], but not for grade 1 and 2 cancers (P = 0.065 and 0.090, respectively). Here, RAD21 is linked to cancer.