Breast cancer overexpress IGF-1R through promoting proliferation and reducing apoptosis to increase bone metastasis [20], the effects of IGF-1R have been confirmed in bone metastasis of prostate cancer [21] but the role of IGF-1R overexpress in NSCLC bone metastasis is not clear, it still needs to be further investigated. The gene discussed is IGF1R; the disease is breast carcinoma.