For example, de Vinuesa et al., 2006 demonstrated the use of the ARB olmesartan (40 mg daily for 16 weeks duration) in 52 adult patients showing typical reductions in systolic and diastolic blood pressure, but also significant reductions in proteinuria, glucose, insulin, insulin resistance (HOMA-IR index), glycated haemoglobin, hsCRP and fibrinogen [96]. This evidence concerns the gene INS and Insulin resistance.