Similarly intraperitoneal administration of WIN55,212-2 or cannabidiol for 3 weeks attenuated the cognitive impairment induced by a single injection of Aβ, although the CB2 agonists, 1,1-dimethylbutyl-1-deoxy-Δ9-tetrahydrocannabinol [JWH-133] and 4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethyl-bicyclo[3.1.1]hept-2-ene-2-methanol [HU-308] did not [34]; in this case the Aβ-induced increase in IL-6 was attenuated by WIN55,212-2 or cannabidiol prompting the authors to conclude that the effect of the cannabinoids resulted from modulation of glial activation. This evidence concerns the gene CNR2 and Cognitive impairment.