For example, Runx2 interaction with p300 alters chromatin structure (acetylation of histones H3 and H4) during activation of MMP-13 gene in bone cell lineage in response to PTH [44] and enhances histone acetylation resulting in increased Snail expression and decreased E-cadherin in lung cancer cells [33]. The gene discussed is RUNX2; the disease is lung carcinoma.