To investigate whether Runx2 suppresses BMP-3B levels in lung cancer cells similar to observed in primary calvarial cells, we stably overexpressed wild type Runx2 (WT) and Runx2 DNA binding domain mutant (DBD) in normal lung fibroblast cells (WI-38 and IMR-90) by lentiviral-mediated gene delivery. This evidence concerns the gene RUNX2 and lung cancer.