To examine whether E2F1 and STAT1 can bind to the MUC4 promoter and whether such an association is induced by nicotine IFN-γ and RA, a series of chromatin immunoprecipitation experiments were carried out on four pancreatic cancer cell lines, namely CD-18/HPAF, ASPC-1, CAPAN-2 and SW1990. This evidence concerns the gene STAT1 and familial pancreatic carcinoma.