Given that E2F1 siRNA and STAT1 siRNA reduces the expression of these transcription factors as expected (Figure 3D), these results in combination with the ChIP assay results, strongly suggest that E2F1 and STAT1 play a major role in mediating the induction of the MUC4 gene in pancreatic cancer cells in response to various upstream signals. The gene discussed is E2F1; the disease is familial pancreatic carcinoma.