It is associated with a group of human neurodegenerative diseases characterized by the presence of filamentous Tau deposits in nerve cells and glial cells [21,22], such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and frontotemporal dementia and parkinsonism linked to chromosome 17(FTDP-17)). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.