Immunohistochemistry was performed to localize periostin, a matricellular protein that has been shown to be expressed at higher levels in keloid fibroblasts than in normal fibroblasts.15 In contrast to normal ESS or nonwounded keloid ESS, high levels of periostin were detected in wounded keloid ESS and were localized to the upper dermis and dermal-epidermal junction in the region of the healing wound (Figs 1g and 1h). The gene discussed is POSTN; the disease is keloid.