The Cancer Genome atlas network (TCGA) has cataloged recurrent genomic abnormalities in GBM and has classified GBM based on abnormalities in the genes encoding PDGFRA, IDH1, EGFR and NF1 GBM into four subgroups: the proneural, neural, classical and mesenchymal, respectively [3]. The gene discussed is NF1; the disease is glioblastoma.