As listed in the table inset in Figure 3B, as a biomarker to distinguish HCC from non-HCC liver diseases, the methylation of the 5′-end of the GSTP1 promoter was significantly more specific than that of the 3′-end (97.1% vs. 60%, p<0.0001 by Fisher's exact test), although the 5′-end was less sensitive than the 3′-end (37.5% vs. 80%), and the AUROC curves for both regions were similar (0.760 and 0.775). The gene discussed is GSTP1; the disease is hepatocellular carcinoma.