Infection with the YY1 knockdown construct resulted in a 50% reduction in cell-surface PSCA levels following R1881 stimulation compared with vector infected Pten CaP8 cells (Figure 5A, lower panel), while YY1 knockdown abrogated the increase in cell-surface PSCA levels in Pten CaP2 cells. The gene discussed is YY1; the disease is infection.