This experiment was conducted to verify the findings in the initial experiment of a hypersensitivity immunopathologic-like reaction after SARS-CoV challenge of vaccinated animals, to determine if a higher dosage of the S protein vaccine (SV) would suppress infection and still exhibit a similar reaction, and whether the original β propiolactone inactivated whole virus vaccine (BPV) that had shown an immunopathologic-like reaction after challenge of vaccinated ferrets and nonhuman primates exhibited a similar immunopathologic reaction in the mouse model [13], [14]. The gene discussed is PROS1; the disease is infection.