Among the first 150 melanomas genotyped with informed consent (from 07/08/2010 to 12/13/2010), 90 (60%) had at least one mutation (Table 3, Figure 2; Table S10), including 57, 23, 6, 3, and 2 mutations in BRAF, NRAS, GNAQ, KIT, and CTTNB1, respectively. The gene discussed is BRAF; the disease is melanoma.