For example, sulindac sulfide is the most potent NAG-1 inducer in colorectal cancer and indomethacin is the most potent in sinonasal cancer [5], [10], [36] These differences are probably related to the complex regulation of NAG-1 expression, which involves both transcriptional and posttranscriptional mechanisms. The gene discussed is GDF15; the disease is colorectal cancer.