A statistical discriminant analysis of 60 anchor SNPs (rs9268831 to rs7764491) showed that the highest average accuracy for predicting RA status is 0.6201 and is associated with SNP16 (rs2027852), which is flanked by HLA-DRB6 and HLA-DRB1. This evidence concerns the gene HLA-DRB6 and rheumatoid arthritis.