RB1 and melanoma: 11 of the 25 molecules described in the introduction as important for melanoma pathogenesis were identified as hubs in the Bayesian gene network: SOX10, CCND1, RB1, and BCL2 all had over 50 children, while PTEN, TYR, CDKN2A, BRAF, PAX3, AKT1 and MITF had between 30 and 50 children.