In TCM cold-pattern RA patients, pathways related to GPI anchor biosynthesis, arachidonic acid metabolism, Jak-STAT signaling, hematopoietic cell lineage, primary immunodeficiency, cytokine-cytokine receptor interaction, ABC transporters, pentose and glucuronate interconversions, and axon guidance were found. Here, SOAT1 is linked to inborn error of immunity.