TLR9 and rheumatoid arthritis: In the heat pattern RA patients, except for the negative regulation of T-cell activation, CTLA4 participates in T-cell-mediated immunity, macrophage activation, and keratinocyte migration with the other seed genes, such as CAMP, SOCS1, HSPA1A, and TLR9. Our study showed that CTLA4 is an important common negative regulator in both cold- and heat-pattern RA patients compared to healthy controls.