For TCM heat-pattern RA patients, closely related pathways, including antigen processing and presentation, endocytosis, MAPK signaling, RNA degradation, hematopoietic cell lineage, complement and coagulation cascades, mTOR signaling, adipocytokine signaling, regulation of autophagy, hypertrophic cardiomyopathy (HCM), and insulin signaling, were found. The gene discussed is INS; the disease is hypertrophic cardiomyopathy.