However, recent trial results have provided no evidence to indicate that rituximab combined with CHOP given every 14 days (R-CHOP14) improves overall survival (OS) or progression-free survival (PFS) compared with the standard regimen of R-CHOP given every 21 days (R-CHOP21) in newly diagnosed DLBCL [31]. Here, DDIT3 is linked to diffuse large B-cell lymphoma.