A multicenter pilot study evaluated the effect of LY333531 (32 mg/day) in T2D patients affected by diabetic nephropathy in addition to their current therapy with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, showing a 25% reduction in urinary albumin creatinine ratio (ACR) after 1 year and a conservation of the estimated GFR level [43]. Here, ALB is linked to type 2 diabetes mellitus.