FGF1 and arterial disorder: In 2007, Sanofi-Aventis started a promising trial (currently ongoing) based on the gene transfer of FGF-1 plasmid DNA in patients with CLI, known as TAMARIS (Therapeutic Angiogenesis for the Management of Arteriopathy in a Randomized International Study) [102], aiming at evaluating the efficacy and safety of intramuscular administration of NV1FGF in CLI patients, a plasmid-based gene delivery system for the local expression of FGF-1 [103, 104] (Table 3).