Pathway identification using the Ingenuity Pathway Analysis software revealed several significant pathways involving regulators of GTPases like Rap1 (SIPA1, a RapGAP protein, and RapGEF2) (Supplementary Figure S4), which pointed toward a significant impact of Rap1 deregulation on melanoma model aggressiveness in vivo. The gene discussed is RAP1GAP; the disease is melanoma.