E-selectin is highly expressed on endothelium in RA synovium, predominantly on venules and capillaries, whereas VCAM-1 and ICAM-1 are also expressed on other cell types, including ST macrophages, fibroblasts, and lymphocytes in RA synovium compared with osteoarthritis synovium [6,18,31]. This evidence concerns the gene VCAM1 and osteoarthritis.