TLR4 and neoplasm: Upon TLR-4 ligation with paclitaxel [13], EOC cells that express MyD88 constitutively secrete pro-inflammatory cytokines, including interleukin (IL)-6, IL-8, vascular endothelial growth factor (VEGF) and monocyte chemotactic protein (MCP), which mediates tumor progression, invasion, metastasis and paclitaxel chemoresponse [14-17].