RESA2 protein as RESA1 has a PEXEL motif and is member of the pHISTb (Plasmodium helical interspersed subtelomeric family) protein family [26] suggesting that as its sister protein RESA1, it could be secreted out of the parasite and contribute in vivo to remodelling the host cell and possibly the erythrocyte membrane so as to favour high-density infections. This evidence concerns the gene COA7 and infection.