A study in 702 white type 2 diabetes subjects reported an association between the tolloid-like 1 (TLL1) gene rs1503298l T/C polymorphism and the number of coronary lesions with ≥20% stenosis independently of age, gender and BMI, and the polymorphism was also associated with the extent of CAD in two independent type 2 diabetes cohorts [44]. The gene discussed is TLL1; the disease is coronary artery disorder.