Using online miRNA target prediction databases (miRNA.org and Targetscan), we hypothesized that metastasis-associated in colon cancer-1 (MACC1), which has been newly identified as a positive prognostic indicator of metastasis formation in CRC [16], was a target of miR-143 (Figure 2A). This evidence concerns the gene MACC1 and malignant colon neoplasm.