SMAD7 and malignant colon neoplasm: Interestingly, the stratified analyses revealed that the rs4939827 (18q21.1) variant's association was limited to women only (OR = 0.6, 95% CI 0.42–0.88, p = 0.007) [75], indicating that common genetic variants in SMAD7 may confer susceptibility to colon cancer particularly among women.