Noteworthy, several candidate susceptibility genes (PRKCA, BMP6, ADAMTS19, ARHGAP6, FUT9/8, FAM108C1, CHL1, BTBD9 and WDR52) are involved in the actin cytoskeleton arrangement, cell adhesion and cell motility processes, which are important for cancer invasion and metastasis. Here, CHL1 is linked to cancer.