Noteworthy, several candidate susceptibility genes (PRKCA, BMP6, ADAMTS19, ARHGAP6, FUT9/8, FAM108C1, CHL1, BTBD9 and WDR52) are involved in the actin cytoskeleton arrangement, cell adhesion and cell motility processes, which are important for cancer invasion and metastasis. This evidence concerns the gene PRKCA and cancer.