Most CRCs are sporadic, and only a small proportion occurs in the course of highly penetrating hereditary syndromes, such as Lynch syndrome, familial adenomatous polyposis and other polyposis syndromes mediated by rare germline mutations in the DNA mismatch repair gene and in the adenomatous polyposis coli (APC) gene [16]. This evidence concerns the gene APC and Familial adenomatous polyposis.