In a therapeutic perspective, inhibition of the PD-1/PD-L1 pathway by anti-PD-1 and anti-PD-L1 antibodies has been described as a successful method of improving the anti-tumor response in multiple murine models of human B-cell malignancies, including acute myeloid leukemia [10], [13], [37]. Here, PDCD1 is linked to acute myeloid leukemia.