Among HIV negative women, 5.7% had abnormal AST or ALT (>35 mg/dl), which was systematically higher with HIV infection and lower CD4, at 7.4%, 8.1% and 11.8% of HIV positive with CD4 count<350, 200–350, and <200 cells/μl respectively, a difference that was not statistically significant by a standard chi-square test, but using a trend test obtained P = 0.024 (data not shown). This evidence concerns the gene CD4 and HIV infectious disease.