In contrast, mutation of the human homologues of Cdc73 (HRPT2/CDC73 or parathrombin), loss of Ctr9, and over-expression of Paf1 have all been associated with cancer [1], and a parathrombin missense mutant both impaired nucleolar localization and promoted growth and survival of NIH3T3 cells [3]. This evidence concerns the gene CDC73 and cancer.