The reconstitution of naïve cd8−/− mice with CD8+ cells from ifnγ−/−pfn+/+ mice (deficient in IFNγ but able to express Pfn) prior to infection had no impact on electrical conduction, which were similar to those found in NR cd8−/− mice, but aggravated cardiomyocyte injury. The gene discussed is IFNG; the disease is infection.