CD8A and cardiomyopathy: Moreover, we demonstrate that the colonization of cardiac tissue of cd8−/− mice by CD8+Pfn+ cells aggravated cardiomyocyte injury, whereas CD8+IFNγ+ cells ameliorated cardiomyocyte injury and electrical abnormalities, thus supporting a differential role for CD8+Pfn+ and CD8+IFNγ+ T-cells in T. cruzi-elicited cardiomyopathy.