Breast cancer characteristics associated with more aggressive disease, ER and PR negativity and HER-2 overexpressing tumours (Gutierrez and Schiff, 2011; Stuckey, 2011) have been associated with an increased risk of brain metastases (Lin and Winer, 2007; Tomasello et al, 2010). This evidence concerns the gene ERBB2 and neoplasm.