To assess the association between serum BAFF/APRIL and disease severity, we counted the number of affected organs from a list of 10 organs (lacrimal glands, salivary glands, lung, pancreas, kidney, retroperitoneum, lymph node, thyroid glands, prostate, and orbit), which are known to be involved in IgG4-RD. This evidence concerns the gene TNFSF13 and immunoglobulin G4-related sclerosing disease.