In fact, elevated serum levels of BAFF were observed in patients with rheumatoid arthritis (RA) [29], systemic lupus erythematosus (SLE) [30], primary Sjögren's syndrome (pSS) [31,32], inflammatory myositis (IM) [33], systemic sclerosis (SSc) [34], bronchial asthma [35], and atopic dermatitis [36], and serum BAFF levels were associated with their clinical activity. This evidence concerns the gene TNFSF13B and Sjogren syndrome.