In the meantime, despite the scarcity of data from RCTs to support their use, there are various secondary preventative measures that can be employed to reduce the risk of OHSS once COS has begun, including canceling the cycle, coasting, individualizing the hCG trigger dose or using a GnRH trigger (for those using a GnRH antagonist protocol), the use of IV fluids at the time of oocyte retrieval, and cryopreserving/vitrifying all oocytes. The gene discussed is GNRH1; the disease is ovarian hyperstimulation syndrome.