INS and cancer: KEGG pathways significantly enriched in these Pax8-regulated genes included vesicle-related terms (endocytosis, rno004144; lysosomes, rno004142), DNA/RNA events, cell cycle, cell-cell interactions (focal adhesions, adherens junctions), cancer-related pathways (MAPK, JAK-STAT, p53, ERBB, TGFβ, and VEGF), amino acid metabolism, and insulin/inositol phosphate signalling events.