In multivariable regression analysis (Table 2), combining established cardiovascular risk factors, BMI (β = 0.105; p = 0.011), history of cardiovascular disease (β = 0.1; p = 0.018) and smoking (β = 0.136; p = 0.001) were positively associated with FGF23, while male sex was inversely associated with FGF23 (β = 0.89; p = 0.032). The gene discussed is FGF23; the disease is cardiovascular disorder.