TNFSF10 and neoplasm: To evaluate the ability of the Tet-On system-controlled sTRAIL expression to suppress tumor cell growth, tumor cell lines of MDA-MB-231, U251, SMMC-7721, SMMC-7402, A549 and HepG2 were exposed for 24 h to the supernatant of HEK293T cells that have been infected with rAAV-TRE-TRAIL&AAV-Tet-On particles at 2 × 105 GPs per cell for 72 h.