TLR3 and neoplasm: Thus TLR3 signaling can contribute to tumor eradication via upregulation of IFN-α and IFN-β, CTL, and NK cell activation, and by signaling through the RIP-1/FADD pathway, whereas it can also indirectly contribute to tumor progression via activation of NF-κB, which can result in proangiogenic factors and subsequent tumor progression.