IDH1 and astrocytic tumor: Since the expression status of mutant IDH1 (isocitrate dehydrogenase 1) has been recently proposed as a prognostic factor in astrocytic tumors [29], Saetta et al. [13] included the IDH1-R132H antibody in their immunohistochemical analysis, which is a surrogate marker of the IDH1 mutant, in a subset of cases in order to evaluate any potential relationship with p-AKT, but the expression of the former was not related neither to nuclear nor to cytoplasmic p-AKT.