EIF4EBP1 and glioblastoma: In vitro experiments have documented sensitization of U87 glioblastoma xenografts to irradiation following 4E-BP1 targeting and decreased hypoxia tolerance, indicating that glioblastomas, which are known to be hypoxic, are expected to rely more on translation regulation pathways for critical functions than their lower grade counterparts [44] thus corroborating the finding of Korkolopoulou et al. [30] that the prognostic effect of 4E-BP1 was established in glioblastomas.