EGFR and anaplastic astrocytoma: A recent phase I dose-escalation trial of gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), plus FSRT (18 to 36 Gy in 3 fractions) in 15 patients (11 GBM, 4 anaplastic astrocytoma) showed this combination was well tolerated at all dose levels.