The serum OPN concentrations of F0/F1 alcoholic patients (14 F0 and 51 F1) were comparable to those found in 16 lean subjects without diagnosed liver complications (BMI = 21±1 kg/m2) and in 14 morbidly obese patients (BMI = 43±1 kg/m2) with a minimal stage of fibrosis (4 F0 and 10 F1) and without hepatic steatosis, inflammation and ballooning (Figure S1). This evidence concerns the gene SPP1 and fatty liver disease.