While OPN was more efficient than the apoptotic marker in estimating significant fibrosis (OPN AUROC versus serum apoptotic marker AUROC: P = 0.0011), OPN, FibroMeter®, hyaluronate and cell death marker levels estimated significant fibrosis with the same accuracy (OPN AUROC versus FibroMeter® AUROC: P = 0.752; versus hyaluronate AUROC: P = 0.791, versus cell death marker AUROC: P = 0.100) indicating that OPN should be an important actor or manifestation of liver fibrosis induced by chronic alcohol consumption. This evidence concerns the gene SPP1 and Hepatic fibrosis.