A detailed analysis of the patient survival further revealed that patients with LGR5+ cancer cells at the luminal surface lived longer (compared with LGR5-negative cases at the luminal surface), while those with LGR5+ tumour cells in the tumour centre and at the invasion front lived shorter compared with LGR5-negative cases at these sites (Table 2; Figure 8). This evidence concerns the gene LGR5 and neoplasm.