PROX1 and LMX1 are both hypermethylated with expression silence in breast cancer and gastric cancer [39], [40], representing 2 in line with the presumed epigenetical markers in the present panel; whereas the expression of TAL1 was closely associated with T cell acute lymphoblastic leukemia and hypermethylation of SLC6A20 with malignant mesothelioma, but the exact underlying mechnism is to be elucidated yet [41], [42]. The gene discussed is PROX1; the disease is breast carcinoma.